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Overview
Aims of the Fellowship in Structural Biology of 14-3-3 Protein Complexes offered by Charles University are:
- structural analysis of 14-3-3 protein complexes with protein kinases ASK1, CaMKKI and CaMKKII using chemical cross-linking, H/D exchange coupled to mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS) and protein crystallography;
- identification and characterization of small molecules that stabilize these complexes. High-throughput screening, fragment-based ligand discovery, and virtual screening will be used to identify initial stabilizers. Subsequently, biophysical and structural methods will be used to characterize these molecules and their stabilizing activity towards their respective 14-3-3 complexes.
Programme Structure
Your key tasks as a PhD student are:- manage and carry out your research project
- pass PhD courses
- write scientific articles and your PhD thesis
- participate in TASPPI ITN training events and international congresses
- stay 6 months abroad working in laboratories of industrial partners of TASPPI project
Key information
Duration
- Part-time
- 36 months
- Flexible
Start dates & application deadlines
- Starting
- Apply before
-
Language
English
Delivered
On Campus
Disciplines
Biology Molecular Sciences Bioinformatics & BiostatisticsAcademic requirements
We are not aware of any academic requirements for this programme.
English requirements
We are not aware of any English requirements for this programme.
Other requirements
General requirements
- Applicants from any country of the world are accepted, but good English skills are mandatory.
- Applicants should have a solid experience with recombinant protein expression and purification. A strong interest in Structural biology, Biophysics and/or Biochemistry is desirable.
- Previous experience with protein crystallography and SAXS is an advantage. A MSc or equivalent degree in a relevant field is required.
- Due to specific requirements of the Marie Skłodowska-Curie Program applicants should not hold PhD degree and, at the time of enrollment in the PhD program in the Czech Republic should have less than 4 years of research experience
- Additionally, at the time of recruitment applicants must not have resided or carried out his/her main activity (work, studies, etc.) in the Czech Republic for more than 12 months in the 3 years before his/her recruitment for the PhD project.
Tuition Fee
Offered PhD position is for 3-4 years with very competitive salary for first three years
Living costs for Prague
15441 - 26241 CZK /month
Living costs
The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.
Funding
Studyportals Tip: Students can search online for independent or external scholarships that can help fund their studies. Check the scholarships to see whether you are eligible to apply. Many scholarships are either merit-based or needs-based.
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