Overview

Aims of the Fellowship in Structural Biology of 14-3-3 Protein Complexes offered by Charles University are:

structural analysis of 14-3-3 protein complexes with protein kinases ASK1, CaMKKI and CaMKKII using chemical cross-linking, H/D exchange coupled to mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS) and protein crystallography;

identification and characterization of small molecules that stabilize these complexes. High-throughput screening, fragment-based ligand discovery, and virtual screening will be used to identify initial stabilizers. Subsequently, biophysical and structural methods will be used to characterize these molecules and their stabilizing activity towards their respective 14-3-3 complexes.

Programme Structure

Your key tasks as a PhD student are:

manage and carry out your research project

pass PhD courses

write scientific articles and your PhD thesis

participate in TASPPI ITN training events and international congresses

stay 6 months abroad working in laboratories of industrial partners of TASPPI project

Key information

Duration

Part-time
- 36 months
- Flexible

Start dates & application deadlines

Starting 2024-10-01 00:00:00
- Apply before 2024-04-17 00:00:00

Language

English

Delivered

On Campus

Disciplines

Biology Molecular Sciences Bioinformatics & Biostatistics View 16 other PhDs in Biology in Czech Republic

Academic requirements

We are not aware of any specific GRE, GMAT or GPA grading score requirements for this programme.

English requirements

We are not aware of any English requirements for this programme.

Student insurance

Make sure to cover your health, travel, and stay while studying abroad. Even global coverages can miss important items, so make sure your student insurance ticks all the following:

Additional medical costs (i.e. dental)
Repatriation, if something happens to you or your family
Liability
Home contents and baggage
Accidents
Legal aid

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Other requirements

General requirements

Applicants from any country of the world are accepted, but good English skills are mandatory.
Applicants should have a solid experience with recombinant protein expression and purification. A strong interest in Structural biology, Biophysics and/or Biochemistry is desirable.
Previous experience with protein crystallography and SAXS is an advantage. A MSc or equivalent degree in a relevant field is required.
Due to specific requirements of the Marie Skłodowska-Curie Program applicants should not hold PhD degree and, at the time of enrollment in the PhD program in the Czech Republic should have less than 4 years of research experience
Additionally, at the time of recruitment applicants must not have resided or carried out his/her main activity (work, studies, etc.) in the Czech Republic for more than 12 months in the 3 years before his/her recruitment for the PhD project.

Tuition Fee

Offered PhD position is for 3-4 years with very competitive salary for first three years

Living costs for Prague

15441 - 26241 CZK /month

Living costs

The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.

Funding

Studyportals Tip: Students can search online for independent or external scholarships that can help fund their studies. Check the scholarships to see whether you are eligible to apply. Many scholarships are either merit-based or needs-based.