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Preventing deaths caused by diseases of heart and circulation in patients with arthritis, Ph.D.

  • Application Deadline
  • 42 months
    Duration
University rank #154 (QS) ,
The insidious progression of cardiovascular disease is a life-threatening feature of several chronic inflammatory diseases (eg rheumatoid arthritis).

About

  • The incidence of cardiovascular disease (CVD) and deaths from cardiovascular causes is higher in patients with rheumatoid arthritis than the general population. The clinical management of patients with rheumatoid arthritis is tailored to alleviating symptoms, disease modification and functional improvement.
  • CVD is unaffected or only reduced slightly by the drugs used conventionally to treat rheumatoid arthritis in the clinic. The prevention or treatments of CVD associated with rheumatoid arthritis is a critical unmet clinical need. This studentship builds upon our proof of concept data; it will provide evidence from basic science research and from disease-relevant human tissues to underpin our case clinical translation.
  • Our working hypothesis: Pharmacological inhibition of Galectins will protect tissues of the heart and aorta from damage and loss of function caused by inflammatory arthritis.

Detailed Programme Facts

  • Programme intensity Full-time
    • Full-time duration 42 months
  • Languages
    • English
  • Delivery mode
    On Campus

Programme Structure

Purpose of the study

  • To deliver a robust package of basic science research and initial proof-of-concept data in humans that validates Galectin blockade in the treatment of cardiovascular disease.
  • To contribute significantly to the existing knowledge in the field of Galectin research.
  • To produce a highly trained researcher who is prepared for employment in academia, science, medicine or non-research industries (e.g., government and the private sector).

This studentship is fully funded by an industrial award from Galecto Biotech. More than 50% of premature deaths in people with rheumatoid arthritis result from cardiovascular disease. The discovery of a drug that prevents vascular injury caused by arthritis is likely to be life-saving.

English Language Requirements

You need the following IELTS score:

  • Minimum required score:

    6.5

    The IELTS – or the International English Language Test System – tests your English-language abilities (writing, listening, speaking, and reading) on a scale of 1.00–9.00. The minimum IELTS score requirement refers to which Overall Band Score you received, which is your combined average score. Read more about IELTS.

    Schedule IELTS

General Requirements

  • Applicants should possess a minimum of an upper second class Honours degree, master's degree, or equivalent in a relevant subject.
  • In some cases, a medical degree and/or relevant professional qualifications or experience are required

Tuition Fee

Living costs for Cardiff

  • 628 - 1070 GBP/month
    Living Costs

The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.

Funding

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