Osteoarthritis affects 8.5 million people in the UK and is a painful, debilitating and progressive condition with no cure apart from eventual surgical removal, fusion or replacement of the affected joint.
Osteoarthritis is commonly secondary to previous joint trauma. Such post-traumatic osteoarthritis (PTOA) accounts for ~12% of the current osteoarthritis population. Since these injuries often arise from sporting activities, individuals affected by PTOA are often affected at a young age (5-15 years after injury).
Not only does this contribute to a significant burden of pain and disability within the working age population, but existing treatments such as joint replacements are less well tolerated in this age group.
One such injury is anterior cruciate ligament (ACL) rupture of the knee, which leads to osteoarthritis in 50% of patients. Many patients will undergo ACL reconstruction surgery to stabilise the joint but, such surgery does not prevent PTOA, and may actually be detrimental due to the inflammation caused.
The project plan represents an ambitious and significant academic challenge for the knowledge base. The interactions between joint biology, joint mechanics and therapeutic outcomes are often poorly understood and difficult to measure, with few efficacy indicators.
The supervisory team applies their expertise in disease mechanisms and functional biomechanics to investigate orthopaedic conditions and thus guide improvements in patient care.
You can apply until:
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This project aims to:
This project is highly interdisciplinary, involving commercial and clinical orthopaedics, bioscience and engineering. Dr Mason and Professor Holt have developed tools and methods of assessment of joint biology and function in arthritic patients. Hospital Innovations, suppliers of specialist orthopaedic products, have successfully collaborated with Mason and Holt to investigate the relationship between biological and biomechanical indicators after knee surgery.
This programme may require students to demonstrate proficiency in English.
The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.
Studyportals Tip: Students can search online for independent or external scholarships that can help fund their studies. Check the scholarships to see whether you are eligible to apply. Many scholarships are either merit-based or needs-based.
Together with the ISIC Association and British Council IELTS, Studyportals offers you the chance to receive up to £10000 to expand your horizon and study abroad. We want to ultimately encourage you to study abroad in order to experience and explore new countries, cultures and languages.
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