Its headquarters are located in the city of Concepción, and also has two other campuses in Chillán and Los Ángeles. In a citizen survey carried out in 2012, it was chosen as the symbol that most identifies Penquists.
The university is located in the University District. The whole campus comprises what is known as the Ciudad Universitaria (University City), which also contains museums, sculptures and parks. Today, the campus has an area of 1,425,000 m2, of which 239,856 are built upon. It is the knowledge, science, culture, technology and research centre of the city of Concepción. The Presencia de América Latina mural by Jorge González Camarena is within the Casa del Arte on the university campus.