Overview
Aims
The Genetic and Developmental Toxicology research program at Heinrich Heine University Düsseldorf has the following objectives:
- analysis of differentiation-dependent alterations of factors that determine the susceptibility of stem (SC) and progenitor cells (PC) to genotoxins
- investigation of the impact of prototypical genotoxins on the efficacy and accuracy of the differentiation process.
The RTG aims for an in-depth characterization of the complex stress responses of SC/PC and the differentiated progeny following genotoxic insults.
In practice, the effects of genotoxins will be analyzed regarding cellular viability and differentiation efficacy of SC/PC as well as the functionality of the differentiated progeny using various murine and human in vitro models.
Programme Structure
Research projects include:- Comparative analyses of DNA damage response pathways in hepatocytes and neurons differentiated from healthy and NBS-patient derived iPSCs
- Hypoxia and Sirtuin 1, two factors linking DNA damage and differentiation in neural stem/ progenitor cells
- Investigations on DNA repair capacities of human neural progenitor cells (NPC) depending on the degree of differentiation and cell type
- Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation
- Impact of genotoxins on autophagic processes during neuronal differentiation
- Effect of DNA damage caused by nephrotoxins and oxidative stress on differentiation and dedifferentiation processes in kidney cells
Key information
Duration
- Full-time
- 36 months
Start dates & application deadlines
- StartingApplication deadline not specified.
Language
Delivered
Disciplines
Toxicology Genetics View 6 other PhDs in Genetics in GermanyAcademic requirements
We are not aware of any specific GRE, GMAT or GPA grading score requirements for this programme.
English requirements
Student insurance
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- Additional medical costs (i.e. dental)
- Repatriation, if something happens to you or your family
- Liability
- Home contents and baggage
- Accidents
- Legal aid
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Other requirements
General requirements
- Normally you need to hold an excellent master's or diploma degree in the appropriate field.
- A good command of English is a requirement for acceptance.
Tuition Fee
-
International
FreeTuition FeeBased on the tuition of 0 EUR per year during 36 months. -
EU/EEA
FreeTuition FeeBased on the tuition of 0 EUR per year during 36 months.
social contribution fee: €321 per semester
Living costs for Düsseldorf
The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.
Funding
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Scholarships Information
Below you will find PhD's scholarship opportunities for Genetic and Developmental Toxicology.
Available Scholarships
You are eligible to apply for these scholarships but a selection process will still be applied by the provider.
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