Novel Functions of the Epigenetic Cancer Driver KMT2D Aston University

Overview

KMT2D, previously also known as MLL2 in humans, is a histone 3 lysine 4 (H3K4) methyltransferase. It has attracted attention as it is within the top 10 most mutated genes in cancer genomes, as well as the main reason behind the congenital disorder Kabuki syndrome. Importantly, in contrast to other cancer genes, the functions of KMT2D have not been clearly established yet. It is believed that KMT2D works through methylating H3K4 in chromatin, a mark of active transcription, and facilitating enhancer mediated transcriptional activation. 

The Novel Functions of the Epigenetic Cancer Driver KMT2D programme at Aston University  will provide all the support and facilities you will need to develop into a leading researcher in your chosen field.  You will be welcomed into a supportive community with a shared enthusiasm for original research, where diversity and multidisciplinary is championed.

Career prospects

Studying for a PhD is a great route into academia and industries that are centred on research and innovation. Areas with a demand for very high level and specialised research skills often demand PhDs.

In addition to this specialist knowledge, a PhD education will help you to develop a set of valuable transferable skills. The very nature of studying an intensive research degree will enable you to become a team player, develop problem-solving skills, analytical thinking, and advanced presentation and communication skills.

The variety of PhD project topics at Aston means that the destinations of our graduates vary substantially. Some choose to continue into academia, at either Aston or other leading institutions, while others go onto use their newly acquired skills in a range of research, healthcare, industry, or charitable fields. When selecting your chosen PhD path at Aston, your supervisor will be able to provide you with relevant career opportunities that could be available to you in your specialist area.