Overview

TargetCaRe is a Marie Sklodowska-Curie Innovative Training Network (MSCA-ITN) on targeting cartilage regeneration in joints and intervertebral disc diseases in the Horzion2020 programme of the European Union. In total, 15 Early Stage Researchers (ESRs) will be appointed by the TargetCaRe consortium for 36 months each.

This post, based at Cardiff University will involve the use of existing (and production of new) monoclonal antibodies (mAbs) that will be coupled to innovative nano-carriers (i.e. nano-ghosts &/or nano-spheres) that have been developed by other collaborators in the consortium. These mAb-nano-carriers will be used to deliver different therapeutic intervention agents (e,g, anti-inflammatory drugs, protease inhibitors &/or growth factors) to specific sites of cartilage/matrix degradation in Osteoarthritis (OA) and Intervertebral Disc (IvD) degeneration to facilitate tissue repair and regeneration of diseased tissue.

Programme Structure

T he Early Stage Researcher will purify mAbs directed at matrix molecules containing either epitopes or neo-epitopes found at specific sites of cartilage/matrix degradation in OA and IvD degeneration. These mAbs will then be coupled to the consortium's recently developed nano-carriers and used in in vitro cell/explant cultures and/or in vivo animal models of OA & IvD pathology to determine their efficacy in targeting & delivering their small molecule or biological cargoes to specific tissue sites with matrix degradation and associated OA or IvD pathology. These proof-of-concept studies will be performed in collaboration with ESRs from other consortium institutions. As part of the Early Stage Researcher position, the successful candidate will be enrolled as a staff candidate for a PhD at Cardiff University.

Audience

The Early Stage Researcher will purify mAbs directed at matrix molecules containing either epitopes or neo-epitopes found at specific sites of cartilage/matrix degradation in OA and IvD degeneration. These mAbs will then be coupled to the consortium's recently developed nano-carriers and used in in vitro cell/explant cultures and/or in vivo animal models of OA & IvD pathology to determine their efficacy in targeting & delivering their small molecule or biological cargoes to specific tissue sites with matrix degradation and associated OA or IvD pathology. These proof-of-concept studies will be performed in collaboration with ESRs from other consortium institutions. As part of the Early Stage Researcher position, the successful candidate will be enrolled as a staff candidate for a PhD at Cardiff University.

Key information

Duration

Full-time
- 36 months

Start dates & application deadlines

Starting 2026-10-01 00:00:00
- Apply before 2026-05-20 00:00:00

More details

October 2015

Language

English

Campus Location

Cardiff, United Kingdom

Disciplines

Biomedical Science Medicine View 218 other PhDs in Medicine in United Kingdom

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Academic requirements

We are not aware of any specific GRE, GMAT or GPA grading score requirements for this programme.

English requirements

We are not aware of any English requirements for this programme.

Other requirements

General requirements

There are strict eligibility requirements for the ESR PhD positions in MSCA-ITN. Please ensure that you qualify before applying, as ineligible candidates cannot be considered.Full details of eligibility requirements can be found on our website: http://courses.cardiff.ac.uk/funding/R2514.html

Tuition Fees

Tuition fees are shown in and the most likely applicable fee is shown based on your nationality.

International Applies to you

Applies to you

Non-residents

Free
EU/EEA Applies to you

Applies to you

EU/EEA Nationals

Free
Domestic Applies to you

Applies to you

Citizens or residents

Free

Funding

This studentship will cover full UK/EU tuition fees, as well as a Doctoral Stipend which marches or exceeeds UK Research Council National Minimum (£14,057 p.a. for 2015/16, updated each year).

One studentship is available.

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Scholarships Information

Below you will find PhD's scholarship opportunities for Fully Funded Early Stage Researcher PhD Position for Cartilage Regeneration in Joints.

Available Scholarships

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