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Evaluating the therapeutic potential of leptin-based hexamers in neurodegenerative disease University of Dundee

36 months
Duration
21940 GBP/year
4786 GBP/year
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Unknown
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Start date

About

In this Evaluating the therapeutic potential of leptin-based hexamers in neurodegenerative disease project at University of Dundee , we will extend this work to examine how leptin-based fragments affect a key pathological trait of AD: build-up of neurofibrillary tangles comprising hyper-phosphorylated tau. 

Overview

Context of Evaluating the therapeutic potential of leptin-based hexamers in neurodegenerative disease project at University of Dundee

Translation of basic research into Alzheimer’s disease (AD) therapies is hindered by our inability to turn promising lab results into drugs that can be taken by patients. One way of addressing this, is to use compounds that we know are safe for human use, in pre-clinical studies examining the network properties that degrade in AD. Our previous work has identified that fragments of the metabolic hormone, leptin, prevent AD-related neurodegeneration and improve the type of memory that is first impaired in AD.

Programme Structure

  • Tau modification and its accumulation in neurons strongly correlate with cognitive deficits and synaptic deficits in early AD. 
  • In healthy neurons, tau is concentrated in axons, but phosphorylation of tau in AD, targets it to synapses where it causes synaptic dysfunction. 
  • Consequently, limiting tau effects on synaptic function may prevent the synaptic abnormalities underlying AD-related cognitive deficits. However, our understanding of how tau impairs synaptic function, and how tau-related synaptic dysfunction can be targeted therapeutically is limited. 
  • Here, we propose to assess the neuroprotective actions of leptin-based fragments in tau models of dementia. This will include using a combination of electrophysiology, and confocal imaging techniques to assess beneficial effects in tau models of synaptic pathology. 

Key information

Duration

  • Full-time
    • 36 months
  • Part-time
    • 60 months

Start dates & application deadlines

Language

English

Delivered

On Campus

What students do after studying

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Academic requirements

GPA admission requirements GPA
Upper Second Class

English requirements

We are not aware of any English requirements for this programme.

Student insurance

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Other requirements

General requirements

  • You should have an honours degree at 2.1 or above, and/or a Masters degree in a relevant discipline.
  • IELTS 7.0

Tuition Fee

To always see correct tuition fees
  • International

    21940 GBP/year
    Tuition Fee
    Based on the tuition of 21940 GBP per year during 36 months.
  • National

    4786 GBP/year
    Tuition Fee
    Based on the tuition of 4786 GBP per year during 36 months.

Band 2

  • National: £9,120
  • International: £26,570

Band 3

  • National: £13,148
  • International: £30,965 or £39,800

Living costs for Dundee

787 - 1494 GBP /month
Living costs

The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.

Funding

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Scholarships Information

Below you will find PhD's scholarship opportunities for Evaluating the therapeutic potential of leptin-based hexamers in neurodegenerative disease.

Available Scholarships

You are eligible to apply for these scholarships but a selection process will still be applied by the provider.

Independent provider
Grant
19000 GBP
Deadline
Not specified
Scholarships for PhD Students
Merit-based

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Junhua Li
Location not available
Independent provider
Grant
15000 USD
Deadline
31 Aug 2025
Amberscholar Scholarship
Merit-based

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Amber Student
Location not available
Independent provider
Grant
Various benefits
Deadline
28 Feb 2025
Boustany Astronomy PhD Scholarship
Merit-based

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Boustany Foundation
Location not available
Independent provider
Grant
Various benefits
Deadline
30 Mar 2025
Aga Khan Foundation International Scholarship Programme
Merit-based

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Aga Khan Foundation
Location not available
Independent provider
Grant
1652 GBP
Deadline
Not specified
Commonwealth Shared Scholarship – University Bids
Merit-based Need-based

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UK Foreign, Commonwealth and Development Office (FCDO)
Location not available
Independent provider
Grant
Various benefits
Deadline
Not specified
Erasmus+ - Grants for study mobility
Merit-based

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OeAD, Austria's Agency for Education and Internationalisation
Location not available
Independent provider
Grant
10000 USD
Deadline
01 Sep 2025
The PhD Prep Fellowship
Merit-based

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Admit Lab
Location not available
Independent provider
Grant
1000 USD
Deadline
09 Jul 2025
Dream Chaser Scholarship
Merit-based

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Salvado Law
Location not available
Independent provider
Grant
90000 AUD
Deadline
Not specified
World Universities Ramsay Postgraduate Scholarship
Merit-based Need-based

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The Ramsay Centre
Location not available
Independent provider
Grant
3000 USD
Deadline
31 Dec 2025
Scholarship for students with disabilities
Need-based

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Anonymous Hope Fund
Location not available
Independent provider
Grant
3000 USD
Deadline
Not specified
AAPG Foundation Grants-in-Aid
Merit-based Need-based

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American Association of Petroleum Geologists Foundation
Location not available
Independent provider
Grant
1000 USD
Deadline
20 May 2025
PlagiarismSearch 2025 Essay Contest
Merit-based

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PlagiarismSearch
Location not available
Independent provider
Grant
1000 USD
Deadline
01 Mar 2025
Voice Talent Online Scholarship
Merit-based Need-based

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Voice Talent Online
Location not available

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Evaluating the therapeutic potential of leptin-based hexamers in neurodegenerative disease
University of Dundee
Evaluating the therapeutic potential of leptin-based hexamers in neurodegenerative disease
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University of Dundee

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