Overview

Techniques:

The student from Targeting Ras palmitoylation for the treatment of cancer at University of Dundee will gain experience of mammalian cell culture, molecular biology techniques (including PCR and site-directed mutagenesis), pharmacology, acyl-RAC (assay for determining protein palmitoylation levels), co-immunoprecipitation and pulldown experiments, SDS-PAGE and Western blotting, protein expression (bacteria, yeast) and purification as well as Hydrogen-Deuterium Exchange (HDX) mass spectrometry.

Programme Structure

Scientific summary: In humans, the genes HRAS, NRAS and KRAS encode three closely related proteins frequently mutated in cancer promoting unregulated cell growth.
Ras proteins function as molecular switches transmitting signals from cell surface growth factor receptors to intracellular effector proteins cycling between inactive (GDP bound) and active (GTP) states.
Oncogenic Ras activity requires the protein to be localised to the inner face of the plasma membrane suggesting strategies that cause Ras to be mistargeted within the cell may be effective in treating cancer.

Key information

Duration

Full-time
- 36 months
Part-time
- 60 months

Start dates & application deadlines

Starting 2025-05-01 00:00:00

Application deadline not specified.
Starting 2025-09-16 00:00:00

Application deadline not specified.
Starting 2026-01-13 00:00:00
- Apply before 2025-10-31 00:00:00

Language

English

Delivered

On Campus

Disciplines

Molecular Sciences Health Sciences View 220 other PhDs in Health Sciences in United Kingdom

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Academic requirements

GPA

Upper Second Class

English requirements

We are not aware of any English requirements for this programme.

Student insurance

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Additional medical costs (i.e. dental)
Repatriation, if something happens to you or your family
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Home contents and baggage
Accidents
Legal aid

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Other requirements

General requirements

You should have an honours degree at 2.1 or above, and/or a Masters degree in a relevant discipline.

IELTS 7.0

Tuition Fee

To always see correct tuition fees

International

21940 GBP/year

Tuition Fee

Based on the tuition of 21940 GBP per year during 36 months.
National

4786 GBP/year

Tuition Fee

Based on the tuition of 4786 GBP per year during 36 months.

Band 2

National: £9,120

International: £26,570

Band 3

National: £13,148

International: £30,965 or £39,800

Living costs for Dundee

787 - 1494 GBP /month

Living costs

The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.