Overview
In this Vascularisation of tumour organoids for mechanistic and drug development project at University of Dundee, the student will gain the practical and intellectual ability to develop, analyse and evaluate in vitro techniques. These skills will including cutting-edge organoid and organ-on-a-chip technology, imaging and statistical analysis, pioneering ways to challenge the current system to enable better modelling.
Context
Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. The development, validation and standardisation of 3D multicellular vascularised-GBM organoid model are required to provide a replacement for in vivo models. A major component to replace in vivo model is to provide vascularisation of GBM organoids and develop a method for standardisation, which can be used for high throughput assays. Banerjee group at the University of Dundee have recently established a human GBM organoid biobank.
Programme Structure
GBM organoids can be vascularised into highly reproducible “chips” to allow for functional physiological assays and screening of drug libraries
- Integration of human vascular (endothelial cells) with human glioblastoma organoids to create a multicellular 3D tumour-on-chip model
- Validation of vascular-glioblastoma model in comparison to literature human and mouse models
- Standardisation of high throughput vascularised-glioblastoma model for drug validation
Key information
Duration
- Full-time
- 36 months
- Part-time
- 60 months
Start dates & application deadlines
- StartingApplication deadline not specified.
- Starting
- Apply before
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- StartingApplication deadline not specified.
Language
Delivered
Campus Location
- Dundee, United Kingdom
Disciplines
Medicine View 219 other PhDs in Medicine in United KingdomWhat students do after studying
Academic requirements
English requirements
We are not aware of any English requirements for this programme.
Other requirements
General requirements
- You should have an honours degree at 2.1 or above, and/or a Masters degree in a relevant discipline.
- IELTS 6.5
Tuition Fees
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International Applies to you
Applies to youNon-residents21940 GBP / year≈ 21940 GBP / year -
Domestic Applies to you
Applies to youCitizens or residents4786 GBP / year≈ 4786 GBP / year
Additional Details
Band 2
- National: £9,120
- International: £26,570
Band 3
- National: £13,148
- International: £30,965 or £39,800
Living costs
Dundee
The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.
Funding
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Scholarships Information
Below you will find PhD's scholarship opportunities for Vascularisation of tumour organoids for mechanistic and drug development.
Available Scholarships
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