Is there a Role for Activated Akt in Palatogenesis, Ph.D. | University of Dundee | Dundee, United Kingdom
36 months
Duration
25410 GBP/year
4825 GBP/year
Unknown
Unknown
Unknown
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Unknown
Start date

About

The Is there a Role for Activated Akt in Palatogenesis project at University of Dundee  will use a medial edge epithelial (MEE) cell line as an in vitro model.

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Overview

Context of  Is there a Role for Activated Akt in Palatogenesis project at University of Dundee

TGF-β3 plays an important role in palatogenesis. The TGFβ-3 homozygous null (-/-) mouse has a cleft palate and treatment of palatal shelves from these knockout mice, ex vivo, with TGFβ-3 causes the palatal shelves to fuse.

 TGFβ-3 may signal via two pathways; the SMAD pathway or the PI-3 kinase/Akt pathway. Blocking of the PI-3 kinase pathway by the inhibitor LY294002 causes the medial edge epithelium to persist in the midline and the basal lamina to remain intact (Kang and Svoboda, 2002), thus no palatal fusion is seen. Epithelial cells of the midline are seen to disappear after fusion and one of the proposed mechanisms for this is epithelial-mesenchymal transition (EMT) which requires PI-3 kinase activity.

 Other possible mechanisms include cell migration and apoptosis. The project will also look for evidence of these events using scratch assays for cell migration and immunocytochemistry with the PAPR-1 antibody for apoptosis.

Programme Structure

  • These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. The resultant data will enable a deeper understanding of the role of TGFβ-3 and the fate of the midline epithelial seam during palatal fusion.

Key information

Duration

  • Full-time
    • 36 months

Start dates & application deadlines

Language

English
TOEFL admission requirements TOEFL® IBT
87

Delivered

On Campus

Academic requirements

GPA admission requirements GPA
Required

English requirements

TOEFL admission requirements TOEFL® IBT
87

Other requirements

General requirements

  • You should have an honours degree at 2.1 or above, and/or a Masters degree in a relevant discipline.

Tuition Fee

To always see correct tuition fees
  • International

    25410 GBP/year
    Tuition Fee
    Based on the tuition of 25410 GBP per year during 36 months.
  • National

    4825 GBP/year
    Tuition Fee
    Based on the tuition of 4825 GBP per year during 36 months.

Living costs for Dundee

787 - 1494 GBP /month
Living costs

The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.

Funding

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Scholarships Information

Below you will find PhD's scholarship opportunities for Is there a Role for Activated Akt in Palatogenesis.

Available Scholarships

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Provided by university
Grant
4000 GBP
Deadline
08 Jan 2025
Vice Chancellor's South Asia scholarship
Merit-based Need-based

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University of Dundee
Dundee, United Kingdom
Provided by university
Grant
6000 GBP
Deadline
08 Jan 2025
Global Excellence Scholarship (January)
Merit-based

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University of Dundee
Dundee, United Kingdom
Independent provider
Grant
50000 INR
Deadline
31 Mar 2024
UniCreds Fly High Scholarship
Merit-based

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Unicreds
Location not available
Independent provider
Grant
Various benefits
Deadline
30 Mar 2024
Aga Khan Foundation International Scholarship Programme
Merit-based

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Aga Khan Foundation
Location not available
Independent provider
Grant
Various benefits
Deadline
Not specified
Full Support for Tuition and Costs of Living- PhD Scholarship at the University of Essex
Merit-based

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Junhua Li
Location not available
Independent provider
Grant
10000 GBP
Deadline
10 Jun 2024
GREAT Scholarship
Merit-based

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British Council - Accreditation UK
Location not available
Independent provider
Grant
3500 USD
Deadline
15 Nov 2024
ACES Scholarships
Merit-based Need-based

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ACES Education Fund
Location not available
Independent provider
Grant
1652 GBP
Deadline
Not specified
Commonwealth Shared Scholarship – University Bids
Merit-based Need-based

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UK Foreign, Commonwealth and Development Office (FCDO)
Location not available
Independent provider
Grant
Various benefits
Deadline
14 Oct 2024
Fulbright U.S. Student Program
Merit-based Need-based

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U.S. government
Location not available
Independent provider
Grant
90000 AUD
Deadline
Not specified
World Universities Ramsay Postgraduate Scholarship
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The Ramsay Centre
Location not available
Independent provider
Grant
3000 USD
Deadline
31 Dec 2025
Scholarship for students with disabilities
Need-based

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Anonymous Hope Fund
Location not available
Independent provider
Grant
12000 USD
Deadline
30 Nov 2024
Tobacco Harm Reduction Scholarship Programme
Merit-based Need-based

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The Tobacco Harm Reduction Scholarship Programme
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Independent provider
Grant
1500 USD
Deadline
15 May 2024
iVisa Annual Scholarship
Merit-based

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iVisa
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Independent provider
Grant
1500 USD
Deadline
31 Mar 2024
The Annual IELTS from 6 to 9 Scholarship
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IELTS from 6 to 9
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Independent provider
Grant
1000 USD
Deadline
29 Feb 2024
Voice Talent Online Scholarship
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Voice Talent Online
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Independent provider
Grant
1000 USD
Deadline
30 Jun 2024
$1,500 Annual Essay Writing Contest Scholarship
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IvyPanda
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Independent provider
Grant
3000 USD
Deadline
Not specified
AAPG Foundation Grants-in-Aid
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American Association of Petroleum Geologists Foundation
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Independent provider
Grant
3000 USD
Deadline
Not specified
Anonymous Hope Fund
Merit-based Need-based

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Anonymous Hope Fund
Location not available
Independent provider
Grant
500 USD
Deadline
30 Apr 2024
Biotin Xtreme Hair Care Annual Scholarship 2023: Empowering The Future Of Hair Care
General Scholarships

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Biotin Xtreme Hair Care
Location not available
Independent provider
Grant
5000 USD
Deadline
10 Mar 2024
“The Hope For Healing” Scholarship
Merit-based Need-based

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FHE Health
Location not available

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