Overview
Context of Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation at University of Dundee
Therefore, the development of PROTACs is a rapidly growing area of research. Additionally, not every E3 ligase can target every protein recruited via PROTACs for degradation, and there have been reports of cancer cells developing a resistance to PROTACs via mutations in E3 ligases. Therefore, the expansion of the PROTAC toolbox by identification and inclusion of novel E3 ligase recruiting molecules is an important and critical step in targeted protein degradation.
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Visit programme websiteProgramme Structure
- With this project, we seek to identify short protein sequences (peptides) capable of recruiting E3 ligases, determine the molecular mechanisms of the interactions and exploit the findings for potential use in novel PROTAC development.
- We have already analysed several novel E3 ligases for their ability to degrade different target proteins and have found a set of four E3 ligases which can efficiently target proteins in different subcellular locations.
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Visit programme websiteKey information
Duration
- Full-time
- 36 months
Start dates & application deadlines
- StartingApplication deadline not specified.
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Disciplines
Physics General Engineering & Technology View 117 other PhDs in Physics in United KingdomExplore more key information
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General requirements
- Send a copy of your CV
- Discuss your potential application and any practicalities (e.g. suitable start date).
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Visit programme websiteTuition Fee
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International
25200 GBP/yearTuition FeeBased on the tuition of 25200 GBP per year during 36 months. -
National
4825 GBP/yearTuition FeeBased on the tuition of 4825 GBP per year during 36 months.
Living costs for Dundee
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