Overview

Context of PI3K-Akt expression in dysplastic oral lesions and implications for recurrence and malignant transformation at University of Dundee

Also determine the efficacy of potential biomarkers such as cell cycle molecules, angiogenic markers and S100 protein expression.

In 2010 the National Screening Committee review (NSC) stated that there is “good evidence that tobacco in all forms (both smoked and smokeless, including snuff) and betel quid are carcinogenic in the upper aerodigestive tract, which includes the mouth. There is also convincing evidence that alcoholic drinks are carcinogenic and act synergistically with tobacco” (Speight & Warnakulasuriya 2010).

Programme Structure

The natural history of oral cancer is only partly understood, with reports of “it is clear that oral squamous cell carcinoma (OSCC) is preceded by changes in the oral mucosa, but the extent or nature of these changes is uncertain” (Speight & Warnakulasuriya 2010).

However, it was also noted that “only about 5% of these lesions will progress to malignancy and although some clinical features are associated with higher risk (e.g. non-homogenous, speckled or red lesions) there are still no reliable ways to predict which individuals or lesions will develop OSCC” (Speight & Warnakulasuriya 2010).
The difficulty in interpreting some of the published work on malignant progression is that many studies do not actually investigate biopsy proven dysplasias but leucoplakias and therefore these may not actually be potentially malignant.

Key information

Duration

Full-time
- 36 months
Part-time
- 60 months

Start dates & application deadlines

Starting 2025-05-01 00:00:00

Application deadline not specified.
Starting 2025-09-16 00:00:00

Application deadline not specified.
Starting 2026-01-13 00:00:00
- Apply before 2025-10-31 00:00:00

Language

English

Delivered

On Campus

Disciplines

Dentistry Health Sciences View 220 other PhDs in Health Sciences in United Kingdom

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Academic requirements

GPA

Upper Second Class

English requirements

We are not aware of any English requirements for this programme.

Student insurance

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Other requirements

General requirements

You should have an honours degree at 2.1 or above, and/or a Masters degree in a relevant discipline.

Non-clinical research: IELTS 6.5

Clinical research: IELTS 7.0

Tuition Fee

To always see correct tuition fees

International

26680 GBP/year

Tuition Fee

Based on the tuition of 26680 GBP per year during 36 months.
National

4786 GBP/year

Tuition Fee

Based on the tuition of 4786 GBP per year during 36 months.

Band 2

National: £9,128

International: £36,855

Band 3

National: £13,148

International: £51,050

Living costs for Dundee

787 - 1494 GBP /month

Living costs

The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.

Funding

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Scholarships Information

Below you will find PhD's scholarship opportunities for PI3K-Akt expression in dysplastic oral lesions and implications for recurrence and malignant transformation.